What can I do about my sister? She's driving me and everyone around her mad.?

My sister, is a very intelligent woman . But due to bad upbringing, her own lack of foresight/motivation, she is in her mid 30s, and she's very un-happy with herself because she never got a career going; but the thing is, instead of just holding her hands up and saying "hey-ho, such is life", she's taking it out on the people around her, telling them that they do not strive enough, or that they do not have enough ambition, or that they don't work hard enough etc etc etc. She has also started spending large amounts of money on her credit card on frivilious things, as if to say "well, if I want it, I can have it, and I'm going to make sure I can, even if it's a charade" basically she's living a lie, and bullying people into making them think that they're failures if they're not happy living a consumeristic, capatalistic way of life. She's making her husband wilt, I'm not talking to her because she's been rude to me, I know that several of her oldest friend's have stopped talking to her. What am I supposed to do? I know that she's taking her frustration out on everyone else, but I don't sympathise anymore. What would you do?